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ea0029p1403 | Pituitary Clinical | ICEECE2012

Pregnancies in a large cohort of patients on growth hormone replacement therapy

Vila G , Akerblad A. , Biller B. , Koltowska-Haggstrom M. , Lundgren F. , Riedl M. , Luger A.

Introduction: Growth hormone replacement (GHRT) during conception and pregnancy is an off-label treatment. Reports on pregnancy outcomes in women with growth hormone deficiency (GHD) are derived from single center studies with small sample sizes and show conflicting results.Methods/design: We evaluate pregnancies reported in the KIMS (Pfizer International Metabolic Database) patients on GHRT. KIMS includes 4651 women aged 1550 years (followed for 1...

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ea0026p216 | Pituitary | ECE2011

Long-term treatment of acromegaly with pegvisomant (Somavert): cross-sectional observations from ACROSTUDY, a post-marketing, international, safety, surveillance study

van der Lely A J , Lundgren F , Biller B M K , Brue T , Cara J , Ghigo E , Hadavi J Hey , Rajicic N , Saller Bernhard , Sanocki John , Strasburger Christian , Webb Susan , Haggstrom Maria Koltowska

Introduction: Somavert is a GH receptor blocker, which inhibits hepatic production of IGF1. While it has been approved for the treatment of acromegaly since 2003 there are few data regarding its effects in everyday clinical practice.Methods/design: ACROSTUDY is an open-label, international, prospective, non-interventional, post-marketing surveillance study monitoring the long-term safety and efficacy of Somavert.Results: As of Dece...

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Endocrine Abstracts

Pregnancies in a large cohort of patients on growth hormone replacement therapy

Long-term treatment of acromegaly with pegvisomant (Somavert): cross-sectional observations from ACROSTUDY, a post-marketing, international, safety, surveillance study

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